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"arthritis natural remedy" posted by ~Ray
Posted on 2008-10-22 07:54:49

The site provides information about the clinical presentation treatment and pathophysiology of rheumatoid arthritis and gouty arthritis treatment osteoarthritis and briefly discusses other types of arthritis. Home help feedback subscriptions archive search table of contents quick search: [advanced] author: keyword(s): year: vol: page: this article full text full text (pdf) alert me when this article gouty arthritis treatment is cited alert me if a correction is posted citation map services similar articles in this journal similar articles in pubmed alert me to new issues of the journal download to citation manager cited by other online articles google scholar articles by otto j. - more gouty arthritis treatment from this site. Dlp gouty arthritis treatment in our eyes is the best investment at least for the next few years. Getting started there is no charge to join gouty arthritis treatment the allbookstores affiliate program. The journal of rheumatology publishing gouty arthritis treatment company limited. More than thirty years ago was able to demonstrate that the source of pain in both osteoarthritis and rheumatoid disease is not in the joints - where most gouty arthritis treatment modern-day treatment lies - but in certain key nerve ganglia leading to the joint. Arthritis crheaim - arthritis com and gouty arthritis treatment best althritee com into active arthritis charge guide hip knee person taking both active arthitis chsrge guid hip knee prson takin arthritis in hands arthritis pain reliever. Arthritis crheaim - arthritis com and gouty arthritis treatment best althritee com into active arthritis charge guide hip active arthitis chsrge guid hip knee prson takin arthritis in hands arthritis pain reliever. I do not recommend you stop taking any drugs gouty arthritis treatment except on the advice of your doctor. South beach diet gouty arthritis treatment recipes 3 weeks. Would you like apple bath epsom gouty arthritis treatment salt vinegar be your own master and honored by all wealthy and.

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"Towards Development of New Arthritis Drugs" posted by ~Ray
Posted on 2007-12-20 23:37:13

has signed an exclusive worldwide authorise agreement with the in order to further develop new treatments for and to put into trials the new RA drugs that Aberdeen has discovered but haven’t been tested yet. Rheumatoid arthritis is a debilitating disease that causes inflammation of the joints which affects some 1% of the worldwide population (or approximately 165 million people. The drugs - which were initially discovered and developed by scientists at the University of Aberdeen - have still to be tested on patients although clinical trials are now expected to go away within two years. The researchers who developed the drugs undergo found that they work in a novel way to suppress the inflammatory affect that is responsible for the development of hit the books and joint damage in patients with arthritis. The researchers believe that the new drugs could provide an important alternative to which is the most effective treatment currently available for rheumatoid arthritis but is expensive and not available to all. Initial tests have shown that one advantage of the new drugs over existing anti-TNF therapy is that they can be taken in tablet form rather than by injection. is a common complication of arthritis (osteoarthritis) and the researchers mentioned above were able to discovering drugs that not only can reduce joint inflammation and joint damage but can also prevent osteoporosis. According to Professor Stuart Ralston. Professor of Rheumatology at the University of Edinburgh: “The identification of these compounds represents an exciting step forward in the fight against arthritis. Our research so far has shown that the drugs work in a unique way and appear to offer potential advantages over existing treatments. We are delighted to be in partnership with Modern Biosciences to further develop this discovery and we very much hope that we will be in a position to go away clinical trials with the new drugs in patients with arthritis over the next two years.” In the said signed agreement. Modern Biosciences will fund and manage the development programme while revenues generated through marketing/sales of any resulting products ordain be shared by the two parties. <a href="" call=""> <abbr call=""> <acronym title=""> <b> <blockquote cite=""> <code> <em> <i> <strike> <strong>

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"The Underreporting Of Arthritis Drug Use? Are You Taking Poison ..." posted by ~Ray
Posted on 2007-12-12 18:35:58

A recent U. S study suggested people underreport their use of these common but potentially dangerous over-the-counter pain medications change surface to their doctors. Unfortunately this practice is risky. NSAIDS undergo known serious side effects. They can damage the liver can create bone marrow problems and can also lead to abnormal kidney answer and kidney failure. Fluid retention aggravation of hypertension and congestive heart failure are other potential problems. In addition. NSAID use has been linked to cardiovascular events such as stroke and heart attack. This latter issue is what caused the removal of Vioxx from the market by the FDA. Most people aren’t aware of the fact though that all NSAIDS- as a class- carry the same type of risk. Because of drug interaction. NSAIDS undergo the ability to alter blood levels of other drugs leading to side-effects. A particularly severe problem can occur in patients who are taking daub thinners like Coumadin (warfarin) and then go away NSAIDS. There are two major pathways that accept normal clotting of daub. NSAIDS check platelet function. Platelets allow clotting of blood via one pathway. In a patient who is taking a blood thinner where the other pathway is also blocked there is the danger of excessive bleeding occurring. Deaths undergo also been reported because of acute allergic reactions that affect the respiratory system or skin. Another set of common but no less potentially life-threatening issues are gastrointestinal complications such as bleeding ulceration and perforation. These problems can occur without causing warning symptoms. Scientists theorize that the pain-relieving properties of these medicines mask the symptoms. With millions of people taking NSAID pain medications daily it's estimated that more than 100,000 U. S citizens are hospitalized each year with ulcers and gastrointestinal bleeding linked to NSAID use. Dr. David Johnson and his colleagues at Eastern Virginia Medical educate surveyed patients at a private gastroenterology learn. Nearly 1-in-5 chew over participants noted use of a NSAID that hadn't been reported verbally to nursing staff including 8 percent who reported daily use. The researchers found 22 percent didn't believe the medications were important enough to report while 30 percent didn't mention use of the drugs because they weren't prescribed by a physician. The authors noted that this practice… reflects a common misperception that these medications are insignificant or benign when actually their chronic use -- particularly among the elderly and those with conditions such as arthritis -- is linked to serious and potentially fatal GI injury and bleeding. The data was presented at the 2007 annual meeting of the American College of Gastroenterology. Author’s say: given the multiplicity of potential side-effects patients should be counseled to report over-the-counter NSAID use. This is particularly important in the older population since this is the assort at greatest assay for complications. Also not to be taken cavalierly is the use of acetaminophen (Tylenol). This medicate when taken chronically can lead to kidney damage as come up as liver alter. A patient ordain sometimes say. “I’m only taking Tylenol…what’s the big broach?”The big broach is that long call use of this analgesic has its own set of safety issues. Bottom lie: There are no 100% completely safe drugs (and that includes herbal remedies). Patients be to inform everything they are taking when they see their physician.

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"Drugs Can Ease Juvenile Rheumatoid Arthritis - US News & World Report" posted by ~Ray
Posted on 2007-12-03 21:11:51

FRIDAY. Nov. 9 (HealthDay News) -- Certain drugs may be effective in treating juvenile rheumatoid arthritis according to studies presented this week at the American College of Rheumatology (ACR) meeting in Boston. This entry was postedon Friday. November 9th. 2007 at 9:07 amand is filed under. You can go any responses to this entry through the feed. Both comments and pings are currently closed. FRIDAY. Nov. 9 (HealthDay News) -- Certain drugs may be effective in treating juvenile rheumatoid arthritis according to studies presented this week at the American College of Rheumatology (ACR) meeting in Boston. This entry was postedon Friday. November 9th. 2007 at 9:07 amand is filed under. You can go any responses to this entry through the cater. Both comments and pings are currently closed.

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"Merck Will Pay $4.85 Billion to Settle Vioxx Lawsuits" posted by ~Ray
Posted on 2007-11-23 15:06:25

Merck & Company says it ordain pay $4.85 billion to lay thousands of lawsuits related to injuries sustained by people who use Vioxx a popular painkiller that was pulled from the merchandise three years ago because studies revealed that it increased the assay of stroke and heart attack. There have been thousands of lawsuits filed in federal and express courts over the past few years. The settlement agreement is intended to resolve these disputes. The $4.85 billion will be placed in a fund for the tens of thousands of Vioxx victims who suffered heart attacks and strokes because they once used the prescription drug. The fund will only be established however if 85% of the plaintiffs agree with the way the claims will be resolved. The agreement consolidates the claims but is not a class-action settlement. Merck had said initially that it would contend every claim based on whether or not the plaintiff had used Vioxx for an extended period of time or whether other factors could have led to the stroke or heart contend. Of the different and lawsuits that have already gone to trial some of them resulted in verdicts in favor of the plaintiffs while other juries rule din favor of Merck. Vioxx is believed to have doubled the risks of cardiovascular problems in populate who had used the drug for more than 18 months. Nearly 20 million people in the United States are estimated to have used Vioxx. Vioxx Vioxx belongs to a category of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Vioxx was used to decrease stiffness hurt and inflammation in patients with osteoarthritis rheumatoid arthritis and certain forms of juvenile rheumatoid arthritis. It was also used to alleviate migraines acute hurt in adults and menstrual pain. Vioxx was been known to cause heart attacks touch death and other serious and not so serious align effects. In Maryland and Washington D. C. the personal injury law firm of Lebowitz and Mzhen represents plaintiffs in claims and lawsuits against manufacturers and corporations that have manufactured or sold products that are not safe for consumers. gratify contact today and ask for your remove consultation with one of our experienced Washington D. C or Maryland products liability lawyers.

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"New Actemra Data Shows Significant Benefit for Patients Suffering ..." posted by ~Ray
Posted on 2007-11-12 07:04:41

BASEL. Switzerland. 7th November 2007 The innovative newrheumatoid arthritis medicate Actemra (tocilizumab) has been shown tosignificantly improve the signs and symptoms of rheumatoidarthritis (RA) in patients who failed to achieve an adequateresponse to traditional disease modifying agents (DMARDs). Excitingnew data from the TOWARD1 study being presented as a late breaker,at the American College of Rheumatology (ACR) Annual ScientificMeeting in Boston. November 6-11 beef up the acquire of tacklingRA through the inhibition of the IL-6 pathway. In the TOWARD trial. 61% of patients in the Actemra plus DMARDgroup achieved a 20% reduction in RA symptoms (ACR202 response)compared with only 25% of patients in the control group. Around onein three patients achieved clinical remission in the Actemra group,as assessed using DAS28 <2.63. These results are consistent withthe results of another Actemra trial the OPTION4 study which werepreviously reported and which will be the affect of furtherpresentations at ACR. The OPTION study showed that 59% of patientsin the Actemra treatment arm experienced a 20% reduction in RAsymptoms (ACR 20 response) versus only 27% of patients in thecontrol group. "We are very encouraged by the findings of this new TOWARD datawhich declare that Actemra plus DMARDs demonstrates significantimprovement in RA symptoms compared with DMARDs alone," said MarkC. Genovese. M. D. lead study investigator of the TOWARD trial andassociate Professor of Medicine at Stanford University School ofMedicine. "These data further open the efficacy of Actemra andconfirm that inhibiting the interleukin-6 (IL-6) receptor is anovel method of reducing RA symptoms." "These results show that remission rates achieved with Actemracompare favourably with current RA therapies indicating themedicine's potential to become a very effective new treatmentoption," said Dr. Urs Schleuniger. Head of Inflammatory Diseases,Roche. "Findings from the TOWARD and OPTION studies will be move ofthe application to Regulatory Authorities that we intend to submitby the end of the year." The TOWARD trial a two-arm double-blind placebo-controlledstudy was designed to evaluate the safety and efficacy of Actemraplus DMARDs compared to placebo plus DMARDs in RA patients. Patients were randomized to acquire either Actemra intravenously(8mg/kg) every four weeks plus DMARDs weekly or placebo infusionsplus DMARDs weekly. The multicentre study treated 1,216 patients at130 trial sites in 18 countries including the U. S. At 24 weeks significantly more patients achieved a 20%. 50% and70% (ACR20. ACR50 and ACR70) reduction of symptoms with Actemraplus DMARDs compared to the hold back group. The ACR20. ACR50 andACR70 was achieved in 61%. 38% and 21% respectively of Actemraplus DMARDs patients versus 25%. 9% and 3% respectively in theplacebo plus DMARDs arm. Disease remission was demonstrated in 30%of Actemra patients (DAS28 <2.6) compared with 3 % of patientstreated with only DMARDs. In the OPTION trial. 623 patients were randomized to receiveActemra intravenously (either 4mg/kg or 8mg/kg) every four weeksplus methotrexate weekly or placebo infusions plus methotrexateweekly. OPTION a three-arm double-blind controlled study,evaluated the safety and efficacy of Actemra plus methotrexatecompared to placebo plus methotrexate in RA patients. The study wasconducted in 73 trial sites in 17 countries outside the UnitedStates. At 24 weeks significantly more patients achieved a 20%. 50%and 70% (ACR20. ACR50 and ACR70) reduction of symptoms with Actemraplus methotrexate compared to the hold back arm. Fifty nine per cent,44% and 22% respectively of patients treated with Actemra(8mg/kg) plus methotrexate achieved ACR20. ACR50 and ACR70 comparedwith 27%. 11% and 2% respectively in the control group. Diseaseremission was demonstrated in 28% of Actemra patients (DAS28<2.6) compared with 1 % of patients treated with methotrexatealone. Other parameters measured in both studies included levels ofC-reactive protein (CRP) a marker of inflammation fatigue andhaemoglobin. Patients on Actemra showed a rapid normalisation ofthe CPR levels within two weeks and a rapid improvement inhaemoglobin levels. According to both studies patients treatedwith Actemra plus DMARDs experienced greater improvements inquality of life and answer measures including fatigue andphysical and mental functions compared to placebo plus DMARDs. Actemra was generally come up tolerated in both studies. The mostcommon adverse events reported more frequently in the Actemra armwere upper respiratory tract infections headache nasopharyngitisand hypertension. As with other disease modifying Other studies The TOWARD1 and OPTION2 trials are two of fivephase III clinical studies designed to evaluate Actemra as apotential new treatment for RA. Two others. emit5 and AMBITION6-are completed and undergo met their primary chew over endpoints. Anadditional phase III trial is ongoing; the two-year study calledLITHE7 and this chew over is expected to report data later in 2008. Allstudies are expected to be presented at upcoming medical meetingsin 2008. Actemra is the first humanised interleukin-6 (IL-6) receptorinhibiting monoclonal antibody and represents a novel mechanism ofaction to treat RA a disease with a high unmet medical be. Theoverall safety compose observed in the global studies of Actemra isconsistent and Actemra is generally come up tolerated. The mostfrequent adverse events reported have included upper respiratorytract infections headache nasopharyngitis and hypertension. Aswith other biological disease modifying anti-rheumatic drugs(DMARDs) serious infections have been reported in some patientstreated with Actemra. Roche and Chugai are collaborating on a phaseIII clinical development programme in RA running outside Japan,with more than 4000 patients enrolled in 41 countries includingseveral European countries and the USA. In lacquer. Actemra waslaunched in June 2005 as a therapy for Castleman's disease and inApril 2006 filed for the additional indications of rheumatoidarthritis and systemic-onset juvenile idiopathic arthritis. About rheumatoid arthritis Rheumatoid arthritis is aprogressive systemic autoimmune disease characterized by chronicinflammation of multiple joints and degenerate as come up as thepossibility of osteoporosis anaemia and lung skin and livereffects. This inflammation causes pain stiffness and swelling,resulting in loss of joint answer due to destruction of the boneand cartilage often leading to progressive disability. advance aschronic inflammation continues there may be shortening of lifeexpectancy as a prove of effects on major organ systems. After 10years less than 50% of patients can continue to work or functionnormally on a day to day basis. RA affects more than 21 millionpeople worldwide. About Roche in rheumatoid arthritis One of the most importantdrivers for growth at Roche over the next few years is expected tobe the company's emerging certify in autoimmune diseases withrheumatoid arthritis as the first indication. Following the launchof MabThera (rituximab) there are a be of projects indevelopment potentially allowing Roche to build on furtheropportunities. MabThera is the first and only selective B-celltherapy for RA providing a fundamentally different treatmentapproach by targeting B cells one of the key players in thepathogenesis of RA. Actemra is Roche's second novel medicine and isa humanised monoclonal antibody to.


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"Immune System Drugs Help IBD" posted by ~Ray
Posted on 2007-11-07 15:56:56

Inflammatory bowel disease is the umbrella call for a number ofconditions that create inflammation of the bowel. The two most common ones areulcerative colitis and Crohn’s disease. Both of these conditions become when theimmune system goes awry and attacks the lining of the colon. The disorders takea knell on their victims - affecting more than 1 million in the U. S alone –causing belly aches diarrhea and other symptoms that are often severe enoughto hinder with daily activities says James B. Lewis. MD associate directorof the inflammatory disease schedule at the University of Pennsylvania inPhiladelphia. “We’re seeing many different approaches to treat thisinflammation,” says Stephen B. Hanauer. MD professor of medicine andclinical pharmacology at the University of Chicago Pritzker educate of Medicine.“For example. [corticosteroids] already used to treat IBD are effectiveanti-inflammatory agents but they alter all tissues causing many sideeffects.” Many of the new drugs on the other hand selectively targetthe defects associated with IBD — an come that promises better resultswith fewer align effects he tells WebMD. A man-made biological substance called a monoclonal antibody,Humira works by blocking an inflammation-causing protein called tumor necrosisfactor alpha or TNF-alpha that has been implicated in both rheumatoidarthritis and Crohn’s disease. In a study of nearly 300 patients who did not improve despitetreatment with standard medications. 30% of those given higher doses of Humirawere in remission by four weeks later compared with only 12% on placebo,Hanauer reports. In another new study the medicate Antegren helped preventflare-ups associated with Crohn’s disease in people who were in remission,reports Brian G. Feagan. MD professor of medicine in the department ofepidemiology and biostatistics at the University of Western Ontario inLondon. Antegren works by keeping immune system cells from leaving thebloodstream. In Crohn’s patients this appears to prevent the immune systemattack on the gut that occurs with the disease. Feagan says. “If we canprevent that white blood cells would be in the circulation where theybelong.” The researchers studied 339 adults with Crohn’s disease who hadimproved or gone into remission after receiving three infusions of Antegren. The patients were randomly assigned to continue to receive Antegren for up to12 additional monthly infusions or to placebo. Six months later. 44% of patients given Antegren were still inremission compared with 26% on placebo. Feagan says. Also. 61% of those takingthe drug continued to show an improvement in symptoms compared with 29% onplacebo.

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"New Arthritis Drugs: Skin Cancer Risk" posted by ~Ray
Posted on 2007-10-30 17:30:03

Aug. 29. 2007 -- Rheumatoid arthritis patients on Remicade or Enbrel have asmall but higher risk of skin cancer a new study confirms. The finding -- from 13,001 rheumatoid arthritis patients who twice a yearcompleted detailed health questionnaires -- underscores recent evidence thathigher doses of new arthritis drugs increase patients' cancer risk. The new study contradicts earlier findings that the new drugs raisepatients' risk of solidtumors. But it supports earlier findings linking the new "TNFblocker" drugs to climb cancers including potentially deadly melanomas. Even so the small risk does not outweigh the acquire for patients who trulyneed the new drugs says study investigator Frederick Wolfe. MD director ofthe National Data tip for Rheumatic Diseases. "These drugs at this moment don't be to add any assay object for skincancer and melanoma," Wolfe tells WebMD. "It is a small overall riskand I don't think populate should be concerned." Rheumatoid arthritis is an immune disease. So-called "TNF blocker"drugs interfere with an immune-system communicate called tumor necrosis factoralpha or TNF-alpha. That can be a huge acquire to populate crippled byrheumatoid arthritis. But it can also subject patients to risks of seriousinfections and cancers. Three of these drugs are approved in the U. S.: Remicade. Enbrel and Humira. The Wolfe chew over,conducted from 1998 through 2005 included very few patients on Humira. Most ofthe chew over patients taking TNF blockers in this chew over used Remicade. A focused on Remicade and Humira (anupdate including Enbrel data is in the works). One of that chew over'sinvestigators. Mayo Clinic rheumatologist Tim Bongartz. MD -- not a participantin the Wolfe chew over -- says Wolfe's findings are similar to those of Swedishinvestigators who also open a link between skin cancer and TNF blockers. "Three major clinical trials in their malignancy data all have someindication there is a problem with skin cancer with these drugs," Bongartztells WebMD. "This has huge implications in how we examine these patientsand how we discuss these patients." Bongartz suggests doctors should do regular thorough whole-body skinexaminations for every patient taking TNF blockers. "If there is a real message in these studies it is that the overallrisk of cancer is small in rheumatoid arthritis patients," he says."The overall cause is to say things are much the same as they have beenover the measure several decades. That is reassuring with these new drugs. ... Idon't evaluate populate should be concerned. It may be these drugs move out to besafe. It looks as though they are and I am not particularly worried." Bongartz says the real cancer risk of TNF blockers remains an open question. Apart from the question of cancer. Bongartz is certain that these drugs doincrease a person's risk of a serious infection. But change surface this he says is noreason for patients who need the drugs to forbid taking them. "It just tells doctors something about how to manage thesepatients," Bongartz says. "If someone turns up in the emergency roomwith vague symptoms if that patient is taking a TNF blocker the doctorsshould be more alert." SOURCES: Wolfe. F and Michaud. K. Arthritis & Rheumatism,September 2007; vol 56: pp 2886-2895. Bongartz. T. The Journal of theAmerican Medical Association. May 17. 2006; vol 295: pp 2275-2285. Frederick Wolfe. MD director. National Data Bank for Rheumatic Diseases,Wichita. Kan. Tim Bongartz. MD division of rheumatology. Mayo Clinic,Rochester. Minn.

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"Arthritis drugs approved for NHS use" posted by ~Ray
Posted on 2007-10-25 19:26:00

The National Institute for Health and Clinical Excellence (NICE) has approved the use of the drug Mabthera (also known as rituximab) for the treatment of rheumatoid arthritis a severe form of the disease. NICE has also recommended the use of the drug Humira (adalimumab) for the treatment of psoriatic arthritis another severe create of arthritis which affects the climb nails and joints. NICE has advised that these drugs can be prescribed for patients with the above conditions who undergo not responded well to other treatments. For more information on the NICE recommendation and on the drugs and conditions mentioned above please click on the links below.

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"Rheumatoid Arthritis Drugs Linked to Slight Skin Cancer Risk" posted by ~Ray
Posted on 2007-10-21 15:28:48

These so-called biologic treatments bring home the bacon by blocking tumor necrosis factor alpha (TNF-alpha) which previous studies had open to be linked with increased assay of skin lung and blood cancers. "The assay of skin cancer is marginally increased among populate with rheumatoid arthritis," said lead researcher Dr. Frederick Wolfe a clinical professor of internal medicine at the University of Kansas School of Medicine. "But it's nothing that anybody should be worried about," he added. For the chew over. Wolfe and his colleagues collected data on 13,001 patients with rheumatoid arthritis included in the National Data Bank for Rheumatic Diseases and the U. S. National Cancer initiate SEER (Surveillance. Epidemiology and End-Results). The researchers open a be of 623 cases of skin cancer and 537 cases of other cancers. They also open that anti-TNF-alpha medications were associated with a brush aside increased risk of skin cancer. But they did not find any increased risk for other cancers according to the inform in the September issue of Arthritis & Rheumatism. The heightened risk for skin cancer is very small. Wolfe emphasized. For melanoma the most serious climb cancer the increased risk is about two-fold; the actual assay is less than one in a thousand patients he said. "This is reassuring data," Wolfe said. "The fact that one didn't sight an increased assay for other cancers looks like in the short term these drugs are safe," he said. One expert agreed that the benefits of TNF-alpha drugs far outweighed the risks to populate with rheumatoid arthritis an autoimmune disease characterized by chronic inflammation of the joints and tissue surrounding vital organs. "The whole issue of the side effects of these biological agents is so controversial and unclarified," said Christopher Evans the Robert W. Lovett professor of orthopedic surgery at the Center for Molecular Orthopaedics at Harvard Medical School. "This study contradicts other studies that suggested greater risks. If the data hold up. I think it's encouraging for patients," he said. "If I were a severe rheumatoid arthritis patient whose quality of life depended upon these drugs. I'd act to act them," he said. "The risk of melanoma is less than the risk of leading a shortened miserable existence." HealthDay procure (c) 2007. All rights reserved.

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"Arthritis drug gets NHS approval BBC TODAY" posted by ~Ray
Posted on 2007-10-11 14:55:36

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"NICE Approval Provides New Drug for Arthritis Patients" posted by ~Ray
Posted on 2007-10-08 14:32:49

In a act described as a “win” by campaigners a new generation of arthritis medicate is set to become available on the NHS. The medicate. MabThera is aimed at patients with arthritis in its severe rheumatoid form and its availability follows approval given by the National Institute for Health and Clinical Excellence under which terms it can be prescribed across England and Wales. The news follows a previous NICE guidance issued only a few days ago in which it was recommended that funding should be withdrawn for the rheumatoid arthritis drug Orencia – an announcement labelled “devastating” by the National Rheumatoid Arthritis Society. However today’s statement opens up the doors for MabThera to be prescribed to English and cheat patients on whom alternative medications have proved ineffective. Rheumatoid arthritis affects approximately 400,000 people in the United Kingdom. The agonising condition occurs when the joints go under attack from the be’s immune system leading to swelling and injuring surrounding bone and cartilage. Within England alone its associated annual health care costs (also taking into be factors like days taken off work) potentially be £1.2 billion. MabThera selectively targets one of the fix immune system cells that contributes to the onset of rheumatoid arthritis. It is manufactured by Roche and its generic name is rituximab. MabThera ordain be prescribed chiefly to patients on the NHS in whom no improvement has been recorded after taking the current generation of anti-TNF drugs. It ordain be prescribed alongside an alternative medication – methotraxate. Describing the significance of NICE’s approval of MabThera. Neil Betteridge – the Chief Executive of Arthritis Care – stated: ”It's a triumph. The examine for effective treatment can be a long agonising journey littered with dashed hopes. Now there is no excuse for denying this drug on any but clinical grounds." Mr Betteridge’s sentiments were echoed by a spokeswoman from the Arthritis investigate Campaign who added: "NICE has been in the firing lie a lot recently so it should be given ascribe for approving the use of rituximab. This gives patients with severe rheumatoid arthritis who disappoint on anti-TNF therapy a life-line by making available another treatment option" It now falls drink to NHS Trusts to verify all patients suitable for MabThera receive it in the coming three months. The rheumatoid arthritis drug is already available on the Scottish NHS following approval granted by NICE’s northern counterpart – the Scottish Medicines Consortium.

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"Arthritis drugs approved for NHS use" posted by ~Ray
Posted on 2007-10-04 04:25:44

populate suffering from arthritis undergo been given new wish today after the government's medicines regulator recommended two drugs be provided on the NHS to treat the condition. The National initiate for Health and Clinical Excellence (Nice) has advised that rituximab (Mabthera) in combination with methotrexate is given to adults with severe active rheumatoid arthritis (RA) who have not responded to or who are intolerant of other anti-rheumatic drugs. populate suffering from active and progressive psoriatic arthritis with three or more tender and swollen joints can now receive adalimumab (Humira) on the NHS. Approximately one per cent of the population suffer from one of these forms of arthritis which can be extremely painful and distressing and effects sufferers' ability to displace out daily activities. RA affects three times as many women as men and has a peak age of onset of 40-70 years. Nice's decision follows an economic analysis of the drugs concluding that "these drugs be the right come for the NHS to take in the treatment of two severe forms of arthritis"."The approval of both of these drugs is good news for anyone suffering from rheumatoid or psoriatic arthritis," said Andrew Dillon. Nice executive lead for the appraisal."By recommending the use of these drugs people in England and Wales with these conditions can be reassured that they have find to effective treatments when they be them."Neil Betteridge chief executive of the charity Arthritis compassionate described Nice's decision as a "triumph"."The examine for effective treatment can be a desire agonising journey littered with dashed hopes," he added. "Now there's no excuse to contradict this medicate on anything but clinical grounds."Arthritis investigate Campaign spokeswoman Jane Tadman commented: "This gives patients with severe rheumatoid arthritis who fail on anti-TNF therapy a life-line by making available another treatment option."

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"NICE gives green light to arthritis drugs" posted by ~Ray
Posted on 2007-10-01 20:27:46

Health attend Sir Ara Darzi is proposing a. One proposal is to undergo private sector surgeries in gyms and supermarkets. Do you conclude this intend will improve patient compassionate? The body which tells the NHS in England and Wales how to spend its prescribing calculate has given the go-ahead to the use of two arthritis drugs. The National initiate for Health and Clinical Excellence (NICE) has today approved the use of rituximab (Mabthera) and adalimumab (Humira) for the treatment of severe arthritis but only when other drugs undergo not worked. An estimated 15% of populate with rheumatoid arthritis have the severe form of the disease while up to 7% of populate with psoriasis create psoriatic arthritis. NICE recommends that rituximab a genetically modified monoclonal antibody should be prescribed with methotrexate for patients with severe active rheumatoid arthritis. But it should only be given to those in whom other disease modifying anti-rheumatic drugs including at least one tumour necrosis factor inhibitor have not worked. Treatment with the drug should be continued only if the patient responds come up it says. Similarly. NICE recommends that adalimumab should be prescribed to adults with progressive and active psoriatic disease. But its use should be restricted to those: The medicate should be discontinued after 12 weeks if there is no adequate response. Both drugs which the NICE recommends should be initially prescribed only by a specialist are expensive. NICE estimates that adalimumab ordain cost the NHS £9,295 a year for every patient treated while the cost of a single course of rituximab based on two 100 mg intravenous infusions is estimated to be £3,492. NICE plans to review the evidence for the drugs next July along with two other arthritis drugs. Etancercept and infliximab. NICE Chief Executive Andrew Dillon said that approval had been granted after the manufacturer had provided further information on the cost of rituximab. NICE had concluded that "these drugs represent the right approach for the NHS to act," he said given the discomfort and bother these severe forms of the disease caused. Arthritis charities welcomed the act. Chief Executive of Arthritis Care hailed the decision as a "win" for patients. "Anti-TNF drugs don't work for everyone," he said. "Left untreated the disease can be severely disabling." But he added: "The examine for effective treatment can be a desire agonising journey littered with dashed hopes." "NICE has shown that it understands the acquire of expanding the be of choices for individuals who undergo exhausted other options and would otherwise approach the bleak prospect of palliative compassionate and go to drugs that undergo already failed them," he said. Dr Andrew Bamji. President of the British Society for Rheumatology echoed the charity's sentiments and commented: "bear witness is mounting that early aggressive treatment of rheumatoid arthritis produces better results and we should not be placed in a lay where our patients are denied the most appropriate treatment." Adalimumab for the treatment of psoriatic arthritis

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"Canine arthritis drugs" posted by ~Ray
Posted on 2007-09-29 04:33:06

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